My bet
Around 2033, for some people first.
Escape velocity won't arrive for everyone on the same day. Like every major technology, the benefits will be uneven at first. They will go to people who adopt new therapies early, measure what happens, and have access to them. Averages will lag years behind. My central guess is that the first people cross that line around 2033.
Some people are already living at the front of the curve (here's what I do). But being an early adopter isn't just about trying new things first. It's about doing it in an informed way, with good clinicians, and measuring what actually happens. That's why I built Selfscope Health, a private tool for tracking your own biology over time. And I'd like those benefits to spread quickly, not stay at the front.